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Kaiso (Zinc Finger and BTB Domain Containing 33, ZBTB33)

Cat no: K0004-01

Kaiso (Zinc Finger and BTB Domain Containing 33, ZBTB33)

Kaiso is a transcriptional represor that belongs to POZ-zinc finger family of transcription factors implicated in development and cancer. It binds to specific methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and it also binds to non-methylated consensus sequence 5'-CTGCNA-3'. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of represive chromatin structures in taget gene promoters. Kaiso may contribute to the repression of target genes of the Wnt signaling pathway.\n\nKaiso is a novel member of the BTB/POZ (Broad complex, Tramtrak, Bric

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SPECIFICATIONS

Catalog Number

K0004-01

Size

100ug

Applications

ELISA, IF, IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat, Can, Ch/Bird

Form

Supplied as a liquid in PBS, pH 7.4, containing 0.1% sodium azide

P Type

Mab

Purity

Purified by Protein A chromatography

Isotype

IgG1

Additional Info

Reacts with the ~95kD Kaiso protein. Reactivity is confirmed with mouse mammary adenocarcinoma cell line CSML0. Reactivity has been confirmed in MDCK (dog), NBTII (rat), HCT116 (human) and chicken embryo fibroblasts.

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