Kir (KIR2D, Killer Cell Immunoglobulin (Ig)-like Receptor, CD158a, CD158b, P50.3) (Azide Free)

KIR2D family members are cell surface glycoproteins with two Ig domains, which are expressed on natural killer cells and some T cells. \n\nApplications:\nSuitable for use in Flow Cytometry, ELISA. Immunoprecipitation, Western Blot and Functional assays. Other applications not tested.\n\nRecommended Dilutions:\nFlow Cytometry: 1:50-1:100. Use 10ul of the optimal working dilution to label 10e6 cells in 100ul.\nOptimal dilutions to be determined by researcher.\n\nRecommended Secondary Reagents: \nI1904-66A: IgG, F(ab

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SPECIFICATIONS

Catalog Number

K1853-02

Size

1mg

Applications

ELISA, FC, IP, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4. No preservative added.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Spaggiari, G.M., et al.: Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily. Blood 99: 1706-1714 (2002). 2. Spaggiari, G.M., et al.: Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. Blood 100: 4098-4107 (2002).

Additional Info

Recognizes KIR2D members of the killer cell immunoglobulin (Ig)-like receptor (KIR) family: CD158a, CD158b and P50.3. Specifically recognizes the long and short forms CD158a and CD158b (KIR2DL, KIR2DS1 and KIR2DS2 respectively) and also p50.3 (KIR2DS4). Reported to have functional activity, activating NK cell cytotoxicity via KIR2DS and inhibiting via KIR2DL forms.