LRP-4 (LRP10, LDL Receptor-related Protein 4 , Low Density Lipoprotein-related Protein 4, MEGF7, LRP13) (PE)

LRP-4 (Low density lipoprotein-related protein 4; also known as MEGF7 and LRP13) is a 220-270kD glycoprotein, member of the LDLR family of proteins. It is expressed on neurons, oocytes, spermatogonia, and skeletal muscle cells and binds multiple ligands, including WISE, ApoE, MuSK, and neuronal Agrin. It serves to negatively regulate Wnt signaling during development, and to cluster AChRs at neuromuscular junctions. Mature human LRP-4 is an 1885 amino acid (aa) type I transmembrane glycoprotein. It contains a 1705aa extracellular domain (ECD; aa21-1725) plus a 159 aa cytoplasmic region (aa1747-1905). In the ECD, there are eight LDLR class A repeats (aa 26-350), two EGF-like repeats (aa354-434) and 20 LDLR class B repeats that contain an intervening EGF-like domain (aa480-1610). Over aa18-344, human LRP-4 shares 88% aa sequence identity with mouse LRP-4.\n\nApplications: \nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 10ul, 1x10e6 cells\nOptimal dilutions to be determined by the researcher.\n\nHybridoma: \nMouse myeloma cells with B cells from Balb/c mice.\n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.

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