Mannan Binding Protein (MBP, Mannose Binding Protein, Mannan Binding Lectin, MBL)

Mannan-binding protein (MBP) is a member of the collectin family, the serum proteins, bovine conglutinin and bovine collectin 43 (CL43), and two lung surfactant proteins (SP-A and SP-D). The collectins bind to terminal non-reducing sugar residues, mannose, GlcNAc, fucose and glucose. SP-D binds to maltose. They play important roles in innate immunity without involvement of antibodies (1). The collectins are characterized by their unusual primary structures and also by their unique three-dimensional structures.\n\nMBP, conglutinin, and CL-43 are synthesized in liver and secreted into the circulation. SP-A and SP-D are mainly synthesized in the lung type II alveolar cells and Clara cells, and secreted into the alveolar space. The serum MBP content increases significantly after birth, and their levels vary greatly even among healthy adult individuals. The serum level increases after infection and remains elevated for longer periods compared with other typical acute phase reactants. The collectins have a consistent feature in the gene organization that the signal peptide, N-terminal segment, and the first few Gly-Xaa-Yaa triplets are encoded by a single exon. The rest of the collagen-like sequences are encoded by one (MBL and SP-A) to four (SP-D and conglutinin) exons. The

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SPECIFICATIONS

Catalog Number

M2250-02

Size

200ug

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1+IgG,2b

References

Super et al. Lancet, 1236-1239 (1989). Super et al. Clin. Exp. Immunol. 79, 144-150 (1990)\nGeneral references:\n1. Lu-J: Collectins: collectors of microorganisms for the innate immune system. BioEssays, 19, 509

Additional Info

Recognizes human MBP.