MASP1 (HC) pAb

MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. MASP-3 is an alternatively spliced product from the MASP-1 gene. The heavy/A chains are identical between MASP-1 and MASP-3 but the light/B chains are entirely different. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.

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SPECIFICATIONS

Catalog Number

BS7033

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human MASP1 heavy chain.

Species

MASP-1 (HC) pAb detects endogenous levels of Mannan-binding lectin serine protease 1 heavy chain.

Dilutions

WB: 1:500~1:1000

Swiss Prot

P48740

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 47 kDa

Alternative Names

Mannan-binding lectin serine protease 1; Complement factor MASP-3; Mannose-binding lectin-associated serine protease 1; MASP-1; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; Mannan-binding lectin serine protease 1 heavy chain; MASP1; CRARF; CRARF1; PRSS5\n