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NUFIP2 (Nuclear Fragile X Mental Retardation Protein Interacting Protein 2, 182-FIP, 82-FIP, 82kD FMRP-interacting Protein, Cell Proliferation-inducing Gene 1 Protein, FIP-82, FLJ10976, FMRP-interacting Protein 2, KIAA1321, MGC117262, Nuclear Fragile X Me

Cat no: N6878-50

NUFIP2 (Nuclear Fragile X Mental Retardation Protein Interacting Protein 2, 182-FIP, 82-FIP, 82kD FMRP-interacting Protein, Cell Proliferation-inducing Gene 1 Protein, FIP-82, FLJ10976, FMRP-interacting Protein 2, KIAA1321, MGC117262, Nuclear Fragile X Me

82kD FMRP Interacting Protein is a novel FMRP-interacting protein associated to polyribosomes as a component of mRNP complexes containing FMRP. FMRP is an RNA binding protein whose absence produces pathological manifestations of the fragile-X syndrome. 82kD FMRP Interacting Protein is found in both nucleus and cytoplasm in some neurons, while it appears only cytoplasmic in others. Subcellular distribution of the protein is cell cycle-dependent in cultured cells. The protein plays a significant role in the development of the nervous system and in cognitive function. Mutation and defect in the protein might be implicated in forms of mental retardation or cognitive impairment. The gene encoding for human 82kD FMRP Interacting Protein is localized on chromosomal region 17q11.2.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:100-1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

N6878-50

Size

100ug

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Barbara, B. et al. Human Molecular Genetics. 12:1689-1698 (2003).

Additional Info

Recognizes human 82kD FMRP Interacting Protein. Species Crossreactivity: mouse.

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SUPPLIER INFO

United States Biological
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