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p-PLC (gamma)2 (Y753) pAb

p-PLC (gamma)2 (Y753) pAb

Cat no: BS4245

Supplier: Bioworld Technology, Inc.
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Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC (beta)1, PLC (beta)2, PLC (beta)3, PLC (beta)4, PLC(gamma)1, PLC(gamma)2, PLC (delta)1, PLC (delta)2 and PLCe. PLC(delta) exists as four different isoforms. PLC (delta)1, a calcium signal amplifier, is activated by an atypical GTP-binding protein. In addition, PLC (delta)1 is an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and (alpha)1B-adrenoreceptor signaling. Mouse PLC (delta)1 is highly expressed in brain, heart, lung and testis. PLC (delta) is abnormally accumulated in autopsied brains with Alzheimer's disease (AD), suggesting that it may play a role in the pathology of AD. PLC (delta)2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma. When PLC (delta)2 is expressed in type I intestinal metaplasia, the metaplasia is generally considered benignant, yet evolves toward neoplastic transformation. Thus, PLC (delta)2 expression may be a possible marker of gastric malignant transformation.
Catalogue number: BS4245
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P16885
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human PLC (gamma)2 around the phosphorylation site of Tyrosine 753.
Species: p-PLC (gamma)2 (Y753) pAb detects endogenous levels of PLC (gamma)2 protein when phosphorylated at Tyr753.
Molecular weight: ~ 148 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2; PLCG2; PLC(gamma)2; PLC-(gamma)2; PLC (gamma)-2
Additional info: For research use only, not for use in diagnostic procedure.

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