PNK1 (PNKP, PNK, polynucleotide kinase 3'-phosphatase, polynucleotide kinase 3-prime-phosphatase)

Alternate Name: PNKP, PNK, polynucleotide kinase 3'-phosphatase, polynucleotide kinase 3-prime-phosphatase\n\nDomain Information: COG4639, Predicted kinase [General function prediction only]; Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]\n\nGene Ontology Terms: DNA repair enzyme; response to DNA damage stimulus; DNA repair; nucleus\n\nApplication(s):\nPeptide ELISA: antibody detection limit dilution 1:16,000. Western Blot: Sucessfully used to detect recombinant human PNKP (1/1000 dilution).\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\n\nPeptide Blocking:\nCorresponding peptide is available for Peptide Blocking studies. See P4340-01B-P. Antibody

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SPECIFICATIONS

Catalog Number

P4340-01B

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW, Lasko DD. , Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage., J Biol Chem. 1999 Aug 20;274(34):24176-86.

Additional Info

Recognizes Human PNKP