Polyethylene Glycol (PEG) (Biotin)

Polyethylene glycol (PEG) is a family of long chain polymers attached to a glycerine backbone. It is a nonionic, nontoxic, biocompatible, strongly hydrophilic polymer, which has a large exclusion volume in aqueous solution. The covalent attachment of PEG is now commonly used to modify a variety of proteins and drugs. The modification of a biopharmaceutical with polyethylene glycol (PEG) increases its hydrodynamic radius, reduces immunogenicity and proteolytic cleavage. Other benefits include decelerated renal excretion, improved stability towards proteolysis and increased solubility of the biopharmaceutical in aqueous solutions. As examples, PEG-adenosine deaminase (Adagen(R)) is used for the treatment of severe combined immunodeficiency syndrome, PEG-asparaginase (Oncaspar(R)) is used for the treatment acute lymphoblastic leukemia, PEG-interferon alpha-2a (Pegasys(R)) is used for the treatment Hepatitis C, Branched PEG-anti-VEGF aptamer (Pegaptanib, Macugen(TM)) is used for the treatment Macular degeneration(age-related). An anti-PEG antibody can be used to monitor a drug's pharmacokinetics, including distribution, metabolism and excretion.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested. \n\nRecommended Dilutions:\nELISA: Do not use in the presence of polymer detergents such as Tween-20.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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