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Polyethylene Glycol (PEG)

Cat no: P4444-27

Polyethylene Glycol (PEG)

Polyethylene glycol?PEG?is a family of long chain polymers attached to a glycerine backbone. It is a nonionic, nontoxic, biocompatible, strongly hydrophilic polymer, which has a large exclusion volume in aqueous solution (1). The covalent attachment of PEG is now commonly used to modify a variety of proteins and drugs (2,3). The modification of a biopharmaceutical with polyethylene glycol (PEG) increases its hydrodynamic radius, reduces immunogenicity and proteolytic cleavage. Other benefits include decelerated renal excretion, improved stability towards proteolysis and increased solubility of the biopharmaceutical in aqueous solutions (4). As examples, PEG-adenosine deaminase (Adagen(R)) is used for the treatment of severe combined immunodeficiency syndrome, PEG

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SPECIFICATIONS

Catalog Number

P4444-27

Size

100ug

Applications

ELISA, IHC, WB

Hosts

Rabbit

Form

Supplied as a liquid, pH 7.4, 0.05% BSA, 0.01% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

1. Guiotto, A. et al. (2004) Anchimeric assistance effect on regioselective hydrolysis of branched PEGs: a mechanistic investigation. Bioorg. Med.Chem. 12, 5031. 2. Wong, S.S. (1991) Reactive groups of proteins and their modifying agents. In Chemistry of protein conjugation and cross-linking, p. 13, CRC Press. 3. Caliceti, P. et al.(1993) Active site protection of proteolytic enzymes by poly(ethylene glycol) surface modification. J. Bioact. Comp. Polym. 8, 41. 4. Frank Leenders, celares GmbH, Berlin, Germany.(2006) PEGylation technology and biopharmaceuticals. Biopharmaceuticals. 6, 39-40. 5. Francesco M.Veronese, Gianfranco Pasut. (2005) PEGylation, successful approach.

Additional Info

Recognizes the terminal methoxy group of the PEG molecule. Detects only conjugated forms of PEG. Does not crossreact with non-specific targets in blood or serum.

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Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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