PRDM4 (PR Domain Zinc Finger Protein 4, PR Domain-containing Protein 4, PFM1)

PRDM4 (PFM1) is a member of the PR-domain family of proteins. Consistent with it functions as a transcription factor, this protein contains six C2H2-type zinc fingers and a SET domain. PRDM4 is found in the nucleus and is expressed in a variety of tissues. It is highly expressed in the pancreas, brain, ovaries, testis, and prostate. Data suggests that this protein plays a role in tumor suppression of ovarian, gastric and pancreatic tumors. PRDM4 is also linked to the NGF signal transduction pathway due to an increase in expression in cells treated with NGF.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.05ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nMouse heart tissue lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

029589

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Mouse, Rat

Form

Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Yang, X.H. and Huang, S. (1999). Genomics. 61(3):319-325.

Additional Info

Recognizes PRDM4 at the C2H2-type 4 region. Species Crossreactivity: mouse and rat. Species sequence homology: Porcine, chimpanzee, rabbit, bovine, canine, giant panda (100%).