Transthyretin (also called prealbumin since it migrates faster than albumin in an acidic starch gel) is a tetrameric human plasma protein consisting of 127 amino acids. It binds to and is known to transport thyroxine and retinol. It is the major component of familial amyloidotic plyneuropathy (FAP) amyloid fibrils. It is known to have approximately sixty amyloidogenic mutational variants. Substitution of only one amino acid occurs in the majority of the variants, with the most frequent being the substitution of valine at position 30 with methionine (Val30Met). The gene TTR that encodes transthyretin is in chromosome region 18q11.2-q12.1.
Applications:
Suitable for use in ELISA or for antigen applications in immunological protocols. Other applications not tested.
Recommended Dilutions:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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