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Prion Protein, Human (Major Prion Protein, PrP, PrP27-30, PrP33-35C, ASCR, CD230, PRNP, PRIP, PRP)

Cat no: P8950-08B

Prion Protein, Human (Major Prion Protein, PrP, PrP27-30, PrP33-35C, ASCR, CD230, PRNP, PRIP, PRP)

P8950-08B is a synthetic peptide from the human prion protein, classified as CD230 at the 7th HLDA workshop. CD230 is a large membrane protein expressed normally in neurons, and thought to be involved in synaptic transmission. In certain diseases, most notably Creutzfeld-Jakob disease (CJD) and bovine spongiform encephalopathy (BSE), normal prion protein (PrPc) is transformed into an altered, pathogenic, form (PrPsc). This altered form is resistant to proteolytic degradation and accumulates in the brains of affected individuals.\n\nSource:\nSynthetic peptide corresponding to KTNMKHMAGAAAAGAC corresponding to aa105-120 of the human prion protein\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

P8950-08B

Size

50ug

Applications

ELISA

Form

Supplied as a liquid in acetate salt.

Purity

~80% (HPLC) analysis

References

1. Forloni, G. et al. (1993) Neurotoxicity of a prion protein fragment Nature, 362: 543-546.

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