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Progesterone Receptor, unactive, Recombinant Human, aa1-160 (Prostaglandin E synthase 3, EC 5.3.99.3, Cytosolic prostaglandin E2 synthase, cPGES, Telomerase-binding protein p23, Hsp90 co-chaperone, Progesterone receptor complex p23)

Cat no: P9007-25A

Progesterone Receptor, unactive, Recombinant Human, aa1-160 (Prostaglandin E synthase 3, EC 5.3.99.3, Cytosolic prostaglandin E2 synthase, cPGES, Telomerase-binding protein p23, Hsp90 co-chaperone, Progesterone receptor complex p23)

Prostaglandin E synthase 3 (PTGES3), also known as P23 or TEBP (Telomerase binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. This protein is a molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Recombinant PTGES3 protein was expressed in E. coli and purified by using conventional chromatography techniques.\n\nSource:\nRecombinant corresponding to human PTGES3, expressed in E. coli. \n\nAA sequence:\nMQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

P9007-25A

Size

100ug

Reactivities

Hum

Form

Supplied as a liquid in 20 mM Tris-HCl, pH8.0, 1mM DTT 10% glycerol.

Purity

~95% (SDS-PAGE) Purified by immunoaffinity chromatography.

References

1.Hawkins GA., et al. (2009) J Allergy Clin Immunol. 123(6):1376-83.e7\n2.Nuttinck F., et al. (2008) Reproduction. 135(5):593-603.

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