Prolactin Receptor, Recombinant, Human (PRL-R)

Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor) which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription. Prolactin (PRL) is a hormone involved in a variety of important functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor, a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40kD to 100kD. The PRL receptor consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

P9009-54H

Size

2ug

Form

Supplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA and 20% glycerol.

Purity

On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 45kD

References

1. The Role of the Bovine Growth Hormone Receptor and Prolactin Receptor Genes in Milk, Fat and Protein Production in Finnish Ayrshire Dairy Cattle.\n\nGenetics 2006 Jun 4;\n\n2. Associations between the prolactin receptor gene polymorphism and reproductive traits of boars.\n\nJ Appl Genet 2006;47(2):139-41\n\n3. A novel estradiol-dependent non-ERE mediated transcriptional mechanism controlling expression of the human prolactin receptor.\n\nJ Biol Chem 2006 May 1;\n\n4. Ligand-Independent Homo- and Hetero-Dimerization of Human Prolactin Receptor Variants: Inhibitory Action of the Short Forms by Heterodimerization.\n\nMol Endocrinol 2006 Mar 23;\n\n5. Long isoform of prolactin receptor predominates in rat intrahepatic bile ducts and further increases under obstructive cholestasis.\n\nJ Endocrinol 2006 Feb;188(2):345-54\n\n6. Prolactin and prolactin receptor expressions in a marine teleost, pufferfish Takifugu rubripes.\n\nGen Comp Endocrinol 2006 May 1;146(3):318-28