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Proliferation-associated 2G4, 38kD, Recombinant, Human (Proliferation Associated Protein 2G4, PA2G4, Cell Cycle Protein p38-2G4 Homolog, ErbB-3 Binding Protein 1, ErbB3-binding Protein 1, EBP1, hG4-1)

Cat no: P9009-96H

Proliferation-associated 2G4, 38kD, Recombinant, Human (Proliferation Associated Protein 2G4, PA2G4, Cell Cycle Protein p38-2G4 Homolog, ErbB-3 Binding Protein 1, ErbB3-binding Protein 1, EBP1, hG4-1)

PA2G4, also known as EBP1 (ErbB-3-binding protein 1), is a member of the peptidase M24C family and functions as an RNA-binding protein involved in cellular proliferation and differentiation processes. It is a component of pre-ribosomal ribonucleoprotein complexes, participating in ribosome assembly and regulating the later steps of rRNA processing. In addition, this protein interacts with ErbB-3 and may function as a modulator of the ErbB-3 mediated signal transduction pathway by regulating the effects of Neuregulin-1. Recombinant human PA2G4 protein, fused to His-tag at C-terminus, was expressed in E. coli.\n\nSource: \nRecombinant corresponding to aa1-270 of human PA2G4 6x His tagged expressed in E. coli.\n\nAA Sequence:\nMSGEDEQQEQ TIAEDLVVTK YKMGGDIANR VLRSLVEASS SGVSVLSLCE KGDAMIMEET GKIFKKEKEM KKGIAFPTSI SVNNCVCHFS PLKSDQDYIL KEGDLVKIDL GVHVDGFIAN VAHTFVVDVA QGTQVTGRKA DVIKAAHLCA EAALRLVKPG NQNTQVTEAW NKVAHSFNCT PIEGMLSHQL KQHVIDGEKT IIQNPTDQQK KDHEKAEFEV HEVYAVDVLV SSGEGKAKDA GQRTTIYKRD PSKQYGLKMK TSRAFFSEVE RRFDAMPFTL RAFEDEKKAR MGVVECAKHE LLQPFNVLYE KEGEFVAQFK FTVLLMPNGP MRITSGPFEP DLYKSEMEVQ DAELKALLQS SASRKTQKKK KKKASKTAEN ATSGETLEEN EAGDLEHHHH HH\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P9009-96H

Size

100ug

Applications

WB

Form

Supplied as a liquid in 20mM Tris HCl, pH 8.0, 10% glycerol.

Purity

~ 95% (SDS-PAGE). Purified by using conventional chromatography techniques.

References

1. Lamartine J. et al. (1997) Cytogenet Cell Genet. 78(1):31-5 2. Yoo JY. et al. (2000) Br J Cancer. 82(3):683-90.

Alternative Names

Proliferation-associated 2G4, 38kDa, p38-2G4

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