Proteasome 20S LMP7 (D6S216, D6S216E, Large Multifunctional Peptidase 7, Large Multifunctional Protease 7, LMP7, LMP-7, Low Molecular Weight Protein 7, Macropain Subunit C13, MGC1491, Multicatalytic Endopeptidase Complex Subunit C13, OTTHUMP00000062981, P

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman

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SPECIFICATIONS

Catalog Number

P9078-38L1

Size

100ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Sheep

Form

Supplied as a liquid in PBS, 0.05% sodium azide.

P Type

Pab

Purity

Purified

Isotype

IgG

References

1. Schwartz AL & Ciechanover A The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 50:57-74 (1999). 2. Voges D et al. The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem 68:1015-68 (1999). 3. Rechsteiner M Ubiquitin-mediated pathways for intracellular proteolysis. Annu Rev Cell Biol 3:1-30 (1987).

Additional Info

Recognizes human proteasome 20S LMP7. Species Crossreactivity: rat, mouse and sheep.