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Protein Tyrosine Phosphatase, Receptor Type F (PTPRF, LCA Homolog, Leukocyte Antigen Related Tyrosine Phosphatase)

Cat no: P9109-40F

Protein Tyrosine Phosphatase, Receptor Type F (PTPRF, LCA Homolog, Leukocyte Antigen Related Tyrosine Phosphatase)

This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. \n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 1:500\nOptimal dilutions to be determined by the researcher.\n\nRecommended Secondary Antibodies: \nI1906: IgY, Chicken Pab Rb x Ch \n I1906-10: IgY, Chicken (HRP) Rb x Ch \nI1906-12: IgY, Chicken (FITC) Rb x Ch \nI1906-14: IgY, Chicken (AP) Rb x Ch \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P9109-40F

Size

50ug

Applications

ELISA, WB

Hosts

Ch/Bird

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgY

Additional Info

Recognizes human Protein Tyrosine Phosphatase, Receptor Type F. Species Crossreactivity: mouse and rat.

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