PSMA (FOLH1, Prostate Specific Membrane Antigen, FGCP, GCP2, GCPII, Mopsm, NAALAD1, NAALADase I) (PerCP)

Human prostate specific membrane antigen (PSMA), a tumor marker in prostate cancer encoded by the FOLH1 gene, is a type II transmembrane zinc metallopeptidase that is most highly expressed in the nervous system, prostate, kidney, and small intestine.1,2 The enzyme is also known as glutamate carboxypeptidase II (GCPII), folate hydrolase 1, folyl-poly-gamma-glutamate carboxypeptidase (FGCP), and N-acetylated alpha-linked acidic dipeptidase I (NAALADase I). In the brain, PSMA hydrolyzes the neurotransmitter N-acetyl-Asp-Glu to produce glutamate, another neurotransmitter. Inhibition of brain PSMA activity is considered to be a promising approach for the treatment of neurological disorders associated with glutamate excitotoxicity, such as stroke, chronic pain, and amyotrophic lateral sclerosis.3 Intestinal PSMA hydrolyzes folyl-poly- gamma-glutamates, facilitating the uptake of folate.4\n\nApplications: \nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 10ul, 1x10e6 cells\nOptimal dilutions to be determined by the researcher.\n\nHybridoma:\nMouse myeloma cells with B cells from Balb/c mice.\n\nStorage and Stability:\nMay be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. PerCP conjugates are sensitive to light.

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SPECIFICATIONS

Catalog Number

145584

Size

100Tests

Applications

FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.5% BSA, 0.09% sodium azide. Labeled with PerCP.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2a

References

1. Silver, D.A. et al. (1997) Clin. Cancer Res. 3:81. 2. Carter, R.E. et al. (1996) Proc.Natl. Acad. Sci. USA 93:749. 3. Jackson, P.F. & B.S. Slusher (2001) Curr. Med. Chem. 8:949. 4. Heston, W.D. (1997) Urology 49:104.

Additional Info

Recognizes human PSMA/FOLH1.