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Rad21 (D548) Peptide

Cat no: BS2422P

Rad21 (D548) Peptide

Rad21 is one of the major cohesin subunits that holds sister chromatids together until anaphase, when proteolytic cleavage by separase, a caspaselike enzyme, allows chromosomal separation. Rad21 interacts with Rec8 to form a cohesin complex that functions in sister chromatid alignment. Rad21 is also involved in the repair of double-strand breaks in DNA and is essential for mitotic growth. Rad21 undergoes a C-terminal cleavage induced by diverse stimuli right before apoptosis. The cleavage product migrates to the cytoplasm and is involved in early events in the apoptotic pathway and it amplifiies the cell death signal in a positive-feedback manner.

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SPECIFICATIONS

Catalog Number

BS2422P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Rad21 (D548). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O60216

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2422 Rad21 (D548) pAb.

Alternative Names

CDLS4; hHR21; HR21; HRAD21; MCD1; NXP 1; NXP-1; Rad 21; RAD21; RAD21 homolog (S. pombe); RAD21 homolog; SCC1; SCC1 homolog;

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