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RAP1GAP Peptide

Cat no: BS5883P

RAP1GAP Peptide

Rap1 GTPase activating protein (Rap1GAP) specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between Galpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and also attenuates the ability of activated Galpha z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to Galpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK.

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SPECIFICATIONS

Catalog Number

BS5883P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide RAP1GAP. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P47736

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS5883 RAP1GAP pAb.

Alternative Names

Rap1 GTPase-activating protein 1; Rap1GAP; Rap1GAP1; KIAA0474; RAP1GA1

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