RGS5 pAb

Regulators of G protein signaling (RGS proteins) are a family of highly diverse, multifunctional signaling proteins that share a conserved 120 amino acid domain (RGS domain). RGS domains bind directly to activated G(alpha) subunits and act as GTPase-activating proteins (GAPs) to attenuate and/or modulate hormone and neurotransmitter receptor-initiated signaling by both G(alpha)-GTP and G(beta)(gamma). RGS proteins shorten the lifetime of activated G proteins. Vascular endothelial cells express the RGS protein RGS5, where it correlates with capillary morphogenesis, thus rendering it a candidate gene involved in capillary growth, angiogenesis, and also potentially the pathophysiology of stroke.

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SPECIFICATIONS

Catalog Number

BS5897

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 130-175 of Human RGS5.

Species

RGS5 pAb detects endogenous levels of RGS5 protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

O15539

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul