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Rho D pAb

Rho D pAb

Cat no: BS5898


Supplier: Bioworld Technology, Inc.
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Upon activation, the small GTPase Rho D (also designated RhoHP1 and ARHD) contributes to rearrangement of the actin cytoskeleton and cell surface and also governs endosome motility and distribution. The effects of Rho D antagonize those of its family member, Rho A, by dissasembling actin stress fibers normally enhanced by Rho A. Additionally, Rho D disengages focal adhesions, resulting in retardation of cell migration. Accordingly, transfection of a constitutively active form of Rho D (designated Rho D G26V) reverses the invasive phenotype of G(alpha)olf induced cells, implying the possiblity of a therapeutic use for activated Rho D in counteracting tumor metastasis.
Catalogue number: BS5898
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug/100ul
Swiss prot: O00212
Dilutions: WB: 1:500~1:1000 ICC: 1:50~1:200 IP: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 156-201 of Human Rho D.
Species: Rho D pAb detects endogenous levels of Rho D protein.
Molecular weight: ~ 23 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Rho-related GTP-binding protein RhoD; Rho-related protein HP1; RhoHP1; RHOD; ARHD
Additional info: For research use only, not for use in diagnostic procedure.

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