Tafazzin (TAZ, TAZ Protein, Taz1, Barth Syndrome, BTHS, Cardiomyopathy Dilated 3A (X-linked), CMD3A, Endocardial Fibroelastosis 2, EFE2, EFE, FLJ27390, HGNC:11577, LVNCX, Protein G4.5, XAP-2)

The tafazzin protein plays a key role in Barth syndrome. Barth syndrome appears to be a disease of the mitochondria. Tafazzin protrudes into the intermembrane space from both the outer and inner membranes. The tafazzin protein may be associated with cardiolipin, the signature lipid of mitochondria, which has been implicated in other diseases, including those of the heart. Tafazzin may be important in repairing lipids, including cardiolipin, but it is not determined. Tafazzin's association with both the outer membrane and the inner membrane is consistent with its ability to modify a membrane component such as cardiolipin.\n\nThis antibody is expected to recognise isoforms 1to 4 (NP_000107.1; NP_851828.1; NP_851829.1; NP_851830.1, respectively).\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T0600-55A

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in TBS, pH 7.2, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

Brandner K, Mick DU, Frazier AE, Taylor RD, Meisinger C, Rehling P.\nTaz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome.\nMol Biol Cell. 2005 Nov;16(11):5202-14\nPMID: 16135531

Additional Info

Species Crossreactivity: Human. Other species have not been tested. Expected crossreactivity based upon sequence homology: Human, Mouse, Rat, canine.