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Tau, phosphorylated (Ser214) (Tau Protein, Microtubule-associated Protein Tau, MAPT, MAPTL, DDPAC, FLJ31424, FTDP-17, MGC138549, MSTD, MTBT1, MTBT2, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau, PPND)

Cat no: T1032-57B

Tau, phosphorylated (Ser214) (Tau Protein, Microtubule-associated Protein Tau, MAPT, MAPTL, DDPAC, FLJ31424, FTDP-17, MGC138549, MSTD, MTBT1, MTBT2, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau, PPND)

Tau is the major microtubule-associated protein in neuronal axons that regulates microtubule stability, neurite outgrowth, and other microtubule -dependent functions. C-terminus of tau protein binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting its role as a linker protein between both. Six tau isoforms are produced in adult human brain by alternative mRNA splicing from a single gene. Filamentous tau protein deposits are the defining characteristic of various neurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as Pick's disease, progressive supranuclear palsy, and corticobasal degeneration. Human tau gene is mapped to chromosome 17q21.1.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:500-1:1000\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nMouse brain tissue\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T1032-57B

Size

50ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Michel, G. et al. Annals of the New York Academy of Sciences. 920:74-83 (2000). 2. Mukrasch, MD. et al. J. Biol. Chem. 282:12230-12239 (2007).

Additional Info

Recognizes human Tau phosphorylated at Ser214. Species Crossreactivity: mouse and rat.

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SUPPLIER INFO

United States Biological

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Bov, Prc

More info

Applications

ELISA, IHC

Hosts

Mouse

Reactivities

Hum, Bov, Prc

More info

Applications

IP

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, IHC

Hosts

Mouse

Reactivities

Hum, Bov, Prc

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

More info

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