Home  >  Products  >  TNKS (Tankyrase-1, TANK1, Poly [ADP-ribose] Polymerase 5A, TNKS-1, TRF1-interacting Ankyrin-related ADP-ribose Polymerase, Tankyrase I, PARP5A, PARPL, TIN1, TINF1, TNKS1)
TNKS (Tankyrase-1, TANK1, Poly [ADP-ribose] Polymerase 5A, TNKS-1, TRF1-interacting Ankyrin-related ADP-ribose Polymerase, Tankyrase I, PARP5A, PARPL, TIN1, TINF1, TNKS1)

TNKS (Tankyrase-1, TANK1, Poly [ADP-ribose] Polymerase 5A, TNKS-1, TRF1-interacting Ankyrin-related ADP-ribose Polymerase, Tankyrase I, PARP5A, PARPL, TIN1, TINF1, TNKS1)

Cat no: T0292-03

Supplier: United States Biological
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Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1.5ug/ml, In transfected HEK293 transiently expressing TANK1 a band of ~142kD is observed. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T0292-03
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T. Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. Cancer Cell. 2005 Jan;7(1):25-37.
Additional info: Recognizes human TNKS.

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