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ULK1 (Serine/Threonine-protein Kinase ULK1, Unc-51-like Kinase 1, KIAA0722)

ULK1 (Serine/Threonine-protein Kinase ULK1, Unc-51-like Kinase 1, KIAA0722)

Cat no: U1500-70D

Supplier: United States Biological
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ULK1 is the mammalian homologue of a C. elegans protein (uncordinated51) involved in neurite growth. The protein is also a homologue of the yeast atg1 protein, a kinase involved in autophagy. The protein constitutes a novel sub-family of serine/threonine kinases. The autophagic role of the protein may be directly linked to neurite growth. The protein is ubiquitously expressed in adult human tissues such as skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung. Both FISH and RH mapping confirmed the regional localization of Ulk1 gene to human chromosome 12q24.3. The protein is also important for axon formation in cerebellar granule neuron and in neurite extension of cerebellar granule cells. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1500-70D
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Kuroyanagi, H. et al. Genomics. 51:76-85 (1998). 2. Nagase, T. et al. DNA Res. 5:277-86 (1999).
Additional info: Recognizes human ULK1. Species sequence homology: mouse, rat, canine.

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