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VSIG4 (V-set and Ig Domain-containing Protein 4, Z39Ig)

Cat no: V4880

VSIG4 (V-set and Ig Domain-containing Protein 4, Z39Ig)

VSIG4 (V-set and Ig domain-containing protein 4; also Z39Ig) is a 45-50kD macrophage-specific protein that belongs to the B7 family of molecules. Its constitutive expression depresses unwarranted T cell activation. Human VSIG4 is 399 amino acids (aa) in length. It is a type I transmembrane (TM) glycoprotein that contains a 264 aa extracellular domain (ECD) (aa 20-283) and a 95 aa cytoplasmic region. The ECD contains one V-type (aa 21-131) and one C2-type Ig-like domain (aa 143-226). Mouse VSIG4 has no C2-type domain. Over aa 20-139, human VSIG4 is 82% aa identical to mouse VSIG4. Multiple splice forms exist in human that impact the ECD and TM segments. One isoform deletes aa 67-143, while two additional isoforms substitute two aa

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SPECIFICATIONS

Catalog Number

V4880

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a lyophilized powder from PBS with 5% trehalose. Reconstitute with 200ul 40-50% glycerol, PBS.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human VSIG4.

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Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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