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(Z)-1,2-Diphenyl-1-(4-hydroxyphenyl)-1-butene

(Z)-1,2-Diphenyl-1-(4-hydroxyphenyl)-1-butene

Cat no: 167098

Supplier: United States Biological
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A metabolite of Tamoxifen, that can be biotransformed to a quinone methide, which has the potential to alkylate DNA and may contribute to the genotoxic effects of tamoxifen. This compound slightly increases intracellular free calcium [Ca2+]i in human platelets and partially inhibits thrombin-induced [Ca2+]i elevation. Solubility: Dichloromethane, Methanol
Catalogue number: 167098
Size: 100mg
Form: Supplied as a White Solid
Alternative names: (Z)-1-(4-Hydroxyphenyl)-1,2-diphenyl-1-butene; (Z)-4-(1,2-Diphenyl-1-butenyl)phenol; ICI 141389; Des-O-dimethylaminoethyl Tamoxifen
References: Dobrydneva, Y. et al.: J. Cardiovasc. Pharm., 50, 380 (2007); Fan, P. & Bolton, J.: Drug. Metab. Dispos., 29, 891 (2001)

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