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United States Biological

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Tranilast (2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid, SB 252218)
Tranilast (2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid, SB 252218)
United States Biological

Cell-permeable. A potent angiogenesis inhibitor. Inhibits VEGF-induced angiogenetic activities. Displays anti-inflammatory and immunomodulatory effects by...

Tiliroside
Tiliroside
United States Biological

A naturally occurring flavonoid that shows anti-complement, anti-inflammatory and free radical scavenger activity. Inhibits the production of the...

Suramin Hexasodium Salt (8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt)
Suramin Hexasodium Salt (8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt)
United States Biological

A P2x and P2y purinergic receptor antagonist that displays antitumor, antiangiogenic and antiparasitic activities. Inhibits sirtuin 1, sirtuin 5 and...

Spautin-1, Autophagy inhibitor (6-Fluoro-N-(4-fluorobenzyl)quinozaline-4-amine)
Spautin-1, Autophagy inhibitor (6-Fluoro-N-(4-fluorobenzyl)quinozaline-4-amine)
United States Biological

Cell-permeable. A specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two...

Skyrin, Talaromyces sp. (Rhodophyscin, Endothianin)
Skyrin, Talaromyces sp. (Rhodophyscin, Endothianin)
United States Biological

A non-peptidic anti-diabetic agent and a receptor-selective glucagon antagonist. Also acts as an antioxidant, free radical and singlet oxygen species...

SKI-II, Sphingosine Kinase Inhibitor (4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol)
SKI-II, Sphingosine Kinase Inhibitor (4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol)
United States Biological

Cell-permeable. SKI-II is selective a non-lipid sphingosine kinase (SK) inhibitor. It displays non-ATP-competitive inhibition of human recombinant GST-SK 1...

SKI-I, Sphingosine Kinase Inhibitor (5-naphthalen-2-yl-2H-pyrazole-3-carboxylic acid (2-hydroxy-naphthalen-1-ylmethylene)-hydrazide)
SKI-I, Sphingosine Kinase Inhibitor (5-naphthalen-2-yl-2H-pyrazole-3-carboxylic acid (2-hydroxy-naphthalen-1-ylmethylene)-hydrazide)
United States Biological

Cell-permeable. SKI-I is a non-lipid pan-sphingosine kinase (SK) inhibitor that inhibits both SK1 and SK2 to suppress the production of pro-mitogenic...

SIRT2 Inhibitor (3-(1-azepanylsulfonyl)-N-(3-bromphenyl)benzamide)
SIRT2 Inhibitor (3-(1-azepanylsulfonyl)-N-(3-bromphenyl)benzamide)
United States Biological

Brain-permeable. A potent and selective sirtuin 2 deacetylase (SIRT2) inhibitor. Reduces neuronal cholesterol by inhibiting SIRT2 activity. Molecular Weight:...

SB-431542 (4-[4-(1,3-Benzodioxol-5-yl)-5-Pyridin-2-yl-1H-Imidz-ol-2-yl]Benzamide)
SB-431542 (4-[4-(1,3-Benzodioxol-5-yl)-5-Pyridin-2-yl-1H-Imidz-ol-2-yl]Benzamide)
United States Biological

A potent and selective inhibitor of the TGF-b1 receptor ALK5 (IC50 = 94nM). It inhibits ALK4 only at higher concentrations (IC50 = 140nM). Suppresses renewal...

Rocaglamide (Rocaglamide A)
Rocaglamide (Rocaglamide A)
United States Biological

An immunosuppressant and a potent inhibitor of NF-kB activation in T cells, with an almost complete inhibition at 200nM. Suppresses cytokine production...

RO-3306, CDK 1 Inhibitor ((5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one)
RO-3306, CDK 1 Inhibitor ((5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one)
United States Biological

Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells....

RO 20-1724, cAMP-specific Phosphodiesterase Inhibitor (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone)
RO 20-1724, cAMP-specific Phosphodiesterase Inhibitor (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone)
United States Biological

Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 microM). Inhibits superoxide generation and platelet...

Pimozide, Stat5 Inhibitor (1-[1-[4,4-bis(4-Fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one)
Pimozide, Stat5 Inhibitor (1-[1-[4,4-bis(4-Fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one)
United States Biological

Cell-permeable. An antipsychotic drug and D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7 receptor. A Stat5 inhibitor;...

PD184352 (Cl-1040, 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide)
PD184352 (Cl-1040, 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide)
United States Biological

PD184352 is an inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK). Molecular Weight: ~478.67 Storage and Stability: May be stored at 4...

Parthenolide ((1aR-[1aR*,4E,7aS*,-10aS*,-10bR*])-2,3-6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclo deca[1,2-b]furan-9(1aH)-one)
Parthenolide ((1aR-[1aR*,4E,7aS*,-10aS*,-10bR*])-2,3-6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclo deca[1,2-b]furan-9(1aH)-one)
United States Biological

An anti-inflammatory agent. Specifically inhibits activation of NF-kB by preventing the degradation of IkBa and IkBb. Inhibits activation of MAP kinase...

NSC-687852, UCHL5 inhibitor (3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one, (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one, b-AP15)
NSC-687852, UCHL5 inhibitor (3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one, (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one, b-AP15)
United States Biological

Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and...

Necrostatin-7 ((Z)-5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one, Nec-7)
Necrostatin-7 ((Z)-5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one, Nec-7)
United States Biological

A necroptosis inhibitor. The biological activity of necrostatin-7 (Nec-7) is different from that of necrostatin-1 to -5 as Nec-7 does not inhibit RIP1...

Necrostatin-1 (5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Methylthiohydantoin-DL-tryptophan, Nec-1)
Necrostatin-1 (5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Methylthiohydantoin-DL-tryptophan, Nec-1)
United States Biological

Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1...

MDBN, p97 Inhibitor (3,4-Methylenedioxy-b-nitrostyrene)
MDBN, p97 Inhibitor (3,4-Methylenedioxy-b-nitrostyrene)
United States Biological

Cell-permeable. An irreversible inhibitor of p97 (IC50 < 10uM). Sequence: 3,4-Methylenedioxy-b-nitrostyrene Molecular Weight: ~193.16 Solubility: DMSO...

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