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![Tranilast (2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid, SB 252218)](/system/suppliers/default_product_images/000/000/160/thumb/US-Biological-Life-Sciences.jpg?1386100414 "Tranilast (2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid, SB 252218)")
Cell-permeable. A potent angiogenesis inhibitor. Inhibits VEGF-induced angiogenetic activities. Displays anti-inflammatory and immunomodulatory effects by...
A naturally occurring flavonoid that shows anti-complement, anti-inflammatory and free radical scavenger activity. Inhibits the production of the...
A P2x and P2y purinergic receptor antagonist that displays antitumor, antiangiogenic and antiparasitic activities. Inhibits sirtuin 1, sirtuin 5 and...
Cell-permeable. A specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two...
A non-peptidic anti-diabetic agent and a receptor-selective glucagon antagonist. Also acts as an antioxidant, free radical and singlet oxygen species...
Cell-permeable. SKI-II is selective a non-lipid sphingosine kinase (SK) inhibitor. It displays non-ATP-competitive inhibition of human recombinant GST-SK 1...
Cell-permeable. SKI-I is a non-lipid pan-sphingosine kinase (SK) inhibitor that inhibits both SK1 and SK2 to suppress the production of pro-mitogenic...
Brain-permeable. A potent and selective sirtuin 2 deacetylase (SIRT2) inhibitor. Reduces neuronal cholesterol by inhibiting SIRT2 activity. Molecular Weight:...
A potent and selective inhibitor of the TGF-b1 receptor ALK5 (IC50 = 94nM). It inhibits ALK4 only at higher concentrations (IC50 = 140nM). Suppresses renewal...
An immunosuppressant and a potent inhibitor of NF-kB activation in T cells, with an almost complete inhibition at 200nM. Suppresses cytokine production...
Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells....
Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 microM). Inhibits superoxide generation and platelet...
Cell-permeable. An antipsychotic drug and D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7 receptor. A Stat5 inhibitor;...
PD184352 is an inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK). Molecular Weight: ~478.67 Storage and Stability: May be stored at 4...
An anti-inflammatory agent. Specifically inhibits activation of NF-kB by preventing the degradation of IkBa and IkBb. Inhibits activation of MAP kinase...
Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and...
A necroptosis inhibitor. The biological activity of necrostatin-7 (Nec-7) is different from that of necrostatin-1 to -5 as Nec-7 does not inhibit RIP1...
Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1...
Cell-permeable. An irreversible inhibitor of p97 (IC50 < 10uM). Sequence: 3,4-Methylenedioxy-b-nitrostyrene Molecular Weight: ~193.16 Solubility: DMSO...
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