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IL-1 (Interleukin-1) is a cytokine responsible for initiating a variety of activities through the activation of transcription factors, NFkB and AP-1, thereby...
Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed...
The genes encoding type I interferons (IFNs), which include 14 IFN-alpha genes, 1 IFN-beta gene, 1 IFN-Omega (also known as IFN-alpha II1) gene, and a number...
The genes encoding type I interferons (IFNs), which include 14 IFN-alpha genes, one IFN-beta gene, one IFN-w (also known as IFN-alpha II1) gene, and a number...
IL-22Ralpha2 (interleukin-22 receptor alpha-2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or...
The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner...
The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18 in a region that is frequently found to be...
The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5,...
STAP-2 is a protein that contains a pleckstrin homology (PH) domain and an SH2 domain, and associates with BRK. BRK (breast tumor kinase, Sik) is a 451 amino...
The double homeobox (DUX) proteins are encoded by 3.3-kilobase repeats found throughout the human genome. The DUX family includes DUX1, DUX2, DUX3, DUX4 and...
Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bisacetamide inducible 2 (HEXIM2) comprise a family of proteins, which inhibit positive...
LZTR1, leucine-zipper-like transcriptional regulator 1, is a member of the BTBkelch superfamily. LZTR1 contains 2 BTB (POZ) domains and 6 Kelch repeats. The...
Cellular nucleic acid binding protein (CNBP) is a highly conserved RNA-binding protein that plays a fundamental biological role in eukaryotic cells by...
Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intrachain...
MAP (mitogen-activated protein) kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and...
The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated...
The superfamily of GTP-binding proteins, for which the Ras proteins are prototypes, has been implicated in regulation of diverse biological activities...
ZADH1 (zinc binding alcohol dehydrogenase,domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2 or 15-oxoprostaglandin 13-reductase, is...
CYP8B1 (sterol 12-alpha-hydroxylase) is a member of the cytochrome P450 superfamily of monooxygenase enzymes that are involved in the metabolism of a wide...
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or...
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