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Three mammalian homologs of baculovirus p35, designated MIHA (mammalian IAP homolog A), MIHB and MIHC have been described. These three mammalian inhibitor of...
Cytosolic malate dehydrogenase (MDHC or cMDH) is an important NAD-dependent enzyme involved in glycometabolism that catalyzes the formation of oxaloacetate...
Indoleamine 2,3-dioxygenase (IDO) is an IFN-(gamma) inducible enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to...
The Wolframin gene encodes a protein found in endoplasmic reticulum membrane of several tissues including brain, pancreas, lung and placenta....
TRPM8 (transient receptor potential cation channel, subfamily M, member 8), also known as TRPP8 or LTRPC6, is a 1,104 amino acid multi-pass membrane protein...
TRB-3 (tribbles 3), also called NIPK (neuronal cell death-inducible protein kinase) disrupts insulin signaling by binding directly to Akt kinases and...
Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting...
ATG13 an autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of...
Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental...
Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to...
Pre-B cell-enhancing factor (PBEF), also designated nicotinamide phosphoribosyltransferase (Nampt) or visfatin, belongs to the NAPRTase family of proteins....
Ecto-nucleotide pyrophosphatase/phospho-diesterase-I enzymes (E-NPP), a group of type II transmembrane proteins, cleave phosphodiester and phosphosulfate...
PANK2 (pantothenate kinase 2), also known as HSS, HARP, PKAN or NBIA1, is a ubiquitously expressed 570 amino acid member of the pantothenate kinase family of...
The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins...
A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The centromere proteins CENP-A, CENP-B, CENP-C, CENP-E,...
The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct...
HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the...
Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a...
Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced...
Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced...
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