Activin

Supplier:

United States Biological

Cat no: A0855-80

Activin

Activin, a disulfide-linked homodimeric protein is secreted by Sertolicells in the testis and granulosa cells in the ovary. In early studies, this peptide was thought to be an inhibin and not recognized as a unique compound. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits have been cloned (mammalian beta A, beta B, beta C, beta E, and Xenopus beta D). The activin/inhibin nomenclature reflects the subunit composition of the proteins: activin A (beta A-beta A), activin B (beta B-beta B), activin AB (beta B-beta A), inhibin A (alpha-beta A) abd inhibin B (alpha-beta B). Activins have a wide range of biological activities including mesoderm induction neural cell differentiation, bone remodeling, hematopoiesis, and reproductive physiology. Activins are also involved in growth and differentiation of several tissues from different species. This protein also plays a key role in the production and regulation of hormones such as FSH, LH, GnRH, and ACTH. Activin influences erythropoiesis and the potentiation of erythroid colony formation, oxytocin secretion, paracrine, and autocrine regulation. Similar to other TGF-beta family members, activins exert their biological activities through the effects of the heterodimeric complex composed of two membrane spanning serine-threonine kinases designated type I and type II receptors. \n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilutions: \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

A0855-80

Size

100ug

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 0.1M Tris HCl, pH 7.5.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgM

Additional Info

Recognizes human Activin.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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