Home  >  Products  >  ACTR1A (ARP1, Actin-Related Protein 1 Homolog A, Centractin alpha (yeast), Actin-RPV, Alpha-Centractin, ARP1, Centractin, Centrosome-associated Actin Homolog, CTRN1)
ACTR1A (ARP1, Actin-Related Protein 1 Homolog A, Centractin alpha (yeast), Actin-RPV, Alpha-Centractin, ARP1, Centractin, Centrosome-associated Actin Homolog, CTRN1)

ACTR1A (ARP1, Actin-Related Protein 1 Homolog A, Centractin alpha (yeast), Actin-RPV, Alpha-Centractin, ARP1, Centractin, Centrosome-associated Actin Homolog, CTRN1)

Cat no: A0857-40

Supplier: United States Biological
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The actin-related protein ACTR1A, a member of the superfamily of actin-related proteins, is the major subunit of the dynactin complex, a key component of the cytoplasmic dynein motor machinery. The major components of the dynactin complex, consisting of at least ten polypeptides, include ACTR1A. ACTR1A, the most abundant subunit in the dynactin complex, is most similar to conventional actin (>50% amino acid identity). The dynactin complex has been shown to localize to multiple structures within the cell, including membrane organelles, the centrosome, spindle poles, and spindle pole microtubules during mitosis and prometaphase kinetochores. It regulates dyneinmediated vesicle movement on microtubules as well as spindle assembly and cell division. ACTR1A overexpression in cells results in aberrant spindle morphologies and cell cycle delay at prometaphase, suggesting a possible function of ACTR1A/dynactin complex in progression through the prometaphase of mitosis. Cellular Localization: Cytoplasmic Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000. Western Blot: 1-3ug/ml. Predicted molecular weight 43kD. Detects a band of ~ 45kD. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A0857-40
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in TBS, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Lees-Miller JP et al. A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. Nature 359:244-6 (1992).
Additional info: This antibody may crossreact with ACTR1B Species Crossreactivity: Crossreacts with Human. Expected to crossreact with Mouse (100% identity with immunogen) and Rat due to sequence homology.

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