Acyclovir (Zovirax) is classified as an antiviral used in the treatment of Herpes genitalis, herpes simplex, herpes zoster and other diseases. Acyclovir inhibits the replication of viral DNA needed to reproduce itself. Phosphorylation by herpes simplex virus thymidine kinase (HSV-TK) leads to the formation of acycloguanosine triphosphate that competitively inhibits the viral DNA polymerase. Acycloguanosine can be used to induce apoptosis in cells transfected with HSV-TK. Inhibits replication of cytomegalovirus by a mechanism that is independent of its phosphorylation by viral or cellular thymidine kinase.
Absorption Coefficient: 603-641
Loss on Drying:
(same/less than)6%
Related Substances:
(same/less than)1%
Heavy Metals:
(same/less than)0.001%
Residue of Ignition: (same/less than)0.1%
Storage & Stability:
May be stored at 4 degrees C. Stable for at least 12 months.
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