ADRA2A (Alpha-2A Adrenergic Receptor, Alpha-2A Adrenoreceptor, Alpha-2A Adrenoceptor, Alpha-2AAR, ADRA2R, ADRAR)

The Alpha 2a- Adrenergic Receptor functions as a post-synaptic receptor that mediates the effects of epinephrine and norepinephrine. This adrenoceptor also functions as a presynaptic autoreceptor, inhibiting the subsequent release of neurotransmitter, especially epinephrine, from sympathetic nerves and from adrenergic neurons in the central nervous system. Adrenergic Alpha-2A Receptor polymorphisms have been identified in individuals with Tourette's syndrome. Furthermore, increased levels of plasma norepinephrine have been noted in children with attention-deficit hyperactivity disorder and learning disabilities. Mutant mice lacking both Alpha 2a and Alpha 2c Receptors exhibited increased plasma noradrenaline and developed cardiac hypertrophy by four months of age.\n\nApplications: \nSuitable for use in Immunofluorescence, ELISA, Western Blot, Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunofluorescence: 1:100-1:500\nELISA: 1:20,000\nWestern Blot: 1:500-1:1000 \nImmunohistochemistry (Paraffin): 10ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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