Axl (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, AXL Transforming Sequence/gene, Adhesion-related Kinase, Ark, Oncogene AXL, Tyrosine Protein Kinase Receptor, UFO, TYR07)

AXL receptor, an 894aa novel Type-I transmembrane protein, is a member of Cell adhesion molecule-related receptor tyrosine kinase family. A chronic myelogeneous leukemia-associated Oncogene, AXL is composed of unique 2 immunoglobulin-like and 2 Fibronectin III repeats in the extracellular region and a C-terminal tyrosine kinase domain. A multi-functional protein mediating Gas6 induced signal transduction; AXL receptor mediates anti-apoptosis, cell proliferation and survival through STAT3 activation, Akt phosphorylation, NF-

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SPECIFICATIONS

Catalog Number

A4776-10D

Size

100ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov, Can

Form

Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

P Type

Pab

Purity

Serum.

Isotype

IgG

References

1. van Ginkel,P.R., Gee,R.L., Shearer,R.L., Subramanian,L., Walker,T.M., Albert,D.M., Meisner,L.F., Varnum,B.C. and Polans,A.S. Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival. Cancer Res. 64 (1), 128-134 (2004). 2. Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor. Blood 105 (5), 1970-1976 (2005). 3. Sainaghi,P.P., Castello,L., Bergamasco,L., Galletti,M., Bellosta,P. and Avanzi,G.C. Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor. J. Cell. Physiol. 204 (1), 36-44 (2005).

Additional Info

Recognizes human AXL. Species Crossreactivity: bovine, canine, mouse, rat.