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BAFF, Soluble, Recombinant, Mouse (Tumor Necrosis Factor Ligand Superfamily Member 13B,  TNFSF13B, B Cell Activating Factor, CD257)

Cat no: 044592

BAFF, Soluble, Recombinant, Mouse (Tumor Necrosis Factor Ligand Superfamily Member 13B, TNFSF13B, B Cell Activating Factor, CD257)

BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. \n\nSequence:\nMouse BAFF (aa 127-309) is fused at the N-terminus to a FLAG(R)-tag.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 6 months after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

044592

Size

10ug

Form

Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.

Purity

>95% (SDS-PAGE)

Additional Info

Binds to human and mouse BAFF-R, TACI and BCMA.

Alternative Names

Tumor Necrosis Factor Ligand Superfamily Member 13B, TNFSF13B, B Cell Activating Factor, CD257

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SUPPLIER INFO

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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