Home  >  Products  >  BAFF, Soluble, Recombinant, Mouse (Tumor Necrosis Factor Ligand Superfamily Member 13B, TNFSF13B, B Cell Activating Factor, CD257)

BAFF, Soluble, Recombinant, Mouse (Tumor Necrosis Factor Ligand Superfamily Member 13B, TNFSF13B, B Cell Activating Factor, CD257)

Cat no: 044592


Supplier: United States Biological
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BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. Sequence: Mouse BAFF (aa 127-309) is fused at the N-terminus to a FLAG(R)-tag. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 6 months after receipt when stored at -20 degrees C.
Catalogue number: 044592
Size: 10ug
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Purity: >95% (SDS-PAGE)
Alternative names: Tumor Necrosis Factor Ligand Superfamily Member 13B, TNFSF13B, B Cell Activating Factor, CD257
Additional info: Binds to human and mouse BAFF-R, TACI and BCMA.

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