Home  >  Products  >  Caspase Inhibitor I (Z-VAD (OMe)-FMK)
Caspase Inhibitor I (Z-VAD (OMe)-FMK)

Caspase Inhibitor I (Z-VAD (OMe)-FMK)

Cat no: 029435

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required. Sequence: Z-Val-Ala-Asp(OMe)-CH2F Solubility: DMSO (50mM) Molecular Weight: ~467.5 Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 029435
Size: 1mg
Form: Supplied as a white solid.
Purity: Single spot by TLC
References: 1. Heng, B.C., et al. 2007. Biosci. Rep. 27, 257. 2. Martin, U., et al. 2007. Apoptosis 12, 525. 3. Misaghi, S., et al. 2004. Chem. Biol. 11, 1677. 4. Joo, C., et al. 1999. Ophthalmic Res. 31, 287. 5. McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229. 6. Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312. 7. Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735. 8. An, S. and Know, K.A. 1996. FEBS Lett. 386, 115. 9. Cain, K., et al. 1996. Biochem J. 314, 27. 10. Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266. 11. Pronk, G.J., et al. 1996. Science 271, 808. 12. Slee, E.A., et al. 1996. Biochem. J. 315, 21. 13. Chow, S.C., et al. 1995. FEBS Lett. 364, 134. 14. Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283. 15. Zhu, H., et al. 1995. FEBS Lett. 374, 303. 15. Heng, B.C., et al. 2007. Biosci. Rep. 27, 257. 16. Naohide Watanabe and Eric Lam. 2005. Journal of Biological Chemistry 280, 14691. 17. Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave