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Products DARPP32, phosphorylated (Thr75) (Dopamine and cAMP-regulated Phosphoprotein, Protein phosphatase 1 regulatory subunit 1B, PP1R1B)
| Catalogue number: | D1075-02K |
| Reactivities: | Human, Mouse, Rat |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Size: | 100ul |
| Form: | As reported |
| P type: | Pab |
| Purity: | Purified by immunoaffinity chromatography. |
| Alternative names: | DARPP 32, DARPP32, Dopamine- and cAMP-regulated neuronal phosphoprotein |
| References: | 1. Svenningsson, P., Tzavara, E.T., Carruthers, R., Rachleff, I., Wattler, S., Nehls, M., McKinzie, D.L., Fienberg, A.A., Nomikos, G.G.and Greengard, P., "Diverse psychotomimetics act through a common signaling pathway," Science, 302 (2003) 1412 - 1415. 2. Lindskog, M., Svenningsson, P., Pozzi, L., Kim, Y., Fienberg, A.A., Bibb, J.A.., Fredholm, B.B., Nairn, A.C., Greengard, P. and Fisone, G., "Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine, Nature (London), 418 (2002) 774 - 778. 3. Maldve, R.E., Zhang, T.A., Ferrani-Kile, K., Schreiber, S.S., Lippmann, M.J., Snyder, G.L., Feinberg, A.A., Leslie, S.W., Gonzales, R.A., and Morrisett, R.A., "DARPP-32 and the regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens," Nature Neurosci. 5 (2002) 641 - 648. 4. Greengard, P., "The neurobiology of slow synaptic transmission," Science 294 (2001) 1024 -1030. 5. Bibb, J.A., Snyder, G.L., Nishi, A., Yan, Z., Meijer, L., Fienberg, A.A., Tsai, L.H., Kwon, Y.T., Girault, J.A., Czernik, A.J., Huganir, R.L., Hemmings, Jr., H.C., Nairn, A.C., and Greengard, P., "Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons, Nature (London) 402 (1999) 669 - 671. 6. Fienberg, A.A., Hiroi, N., Mermelstein, P.G., Song, W., Snyder, G.L., Nishi, A., Cheramy, A. O'Callaghan, J.P., Miller, D.B., Cole, D.G., Corbett, R., Haile, C.N., Cooper, D,C., Onn, S.P., Grace, A.A., Ouimet, C.C., White, F.G., Hyman, S.E., Surmeier, D.G., Girault, J., Nestler, E.J., and Greengard, P., "DARPP-32: regulator of the efficacy of dopaminergic neurotransmission," Science 281 (1998) 838 - 842. 7. Walaas, S.I. and Greengard, P., "DARPP-32, A dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions," J. Neurosci. 4 (1984) 84 -98. 8. Han, J., Han, L., Tiwari, P., Wen, Z., and Zheng, J. Q. (2007) Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP, 176, 101-111. |
| Additional info: | Specific for the ~34k DARPP-32 phosphorylated at Thr75. Species Crossreactivity: This antibody recognizes human, mouse, and rat forms of the protein. Other species have not been tested. |
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