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DAXX (Death Domain-associated Protein 6, hDaxx, ETS1-associated Protein 1, EAP1, Fas Death Domain-associated Protein, BING2, DAP6)

DAXX (Death Domain-associated Protein 6, hDaxx, ETS1-associated Protein 1, EAP1, Fas Death Domain-associated Protein, BING2, DAP6)

Cat no: D1150-05H

Supplier: United States Biological
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Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000 Immunoprecipitation: 1:50-1:200 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Prostate cancer, thymus, testes Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D1150-05H
Reactivities: Human, Mouse, Rat, Bovine, Canine, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 50ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Salomoni P and AF Khelifi. 2006. Daxx:death or survival protein? TRENDS in Cell Biol. 16:97-104.
Additional info: Recognizes human DAXX. Species Crossreactivity: bovine, canine, monkey, rat. Species sequence homology: mouse.

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