Home  >  Products  >  DcR2 (Decoy Receptor 2, CD264, TNF-related Apoptosis-inducing Ligand Receptor 4, TRAIL Receptor 4, TRAILR4, TRAIL-R4, TRAIL Receptor with a Truncated Death Domain, TRUNDD, Tumor Necrosis Factor Receptor Superfamily Member 10D, TNFRSF10D, UNQ251/PRO288)
DcR2 (Decoy Receptor 2, CD264, TNF-related Apoptosis-inducing Ligand Receptor 4, TRAIL Receptor 4, TRAILR4, TRAIL-R4, TRAIL Receptor with a Truncated Death Domain, TRUNDD, Tumor Necrosis Factor Receptor Superfamily Member 10D, TNFRSF10D, UNQ251/PRO288)

DcR2 (Decoy Receptor 2, CD264, TNF-related Apoptosis-inducing Ligand Receptor 4, TRAIL Receptor 4, TRAILR4, TRAIL-R4, TRAIL Receptor with a Truncated Death Domain, TRUNDD, Tumor Necrosis Factor Receptor Superfamily Member 10D, TNFRSF10D, UNQ251/PRO288)

Cat no: D1500-05A

Supplier: United States Biological
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Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL/R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 Optimal dilutions to be determined by the researcher. Positive Control: HeLa Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D1500-05A
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
Alternative names: Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain
References: 1. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM. The receptor for the cytotoxic ligand TRAIL. Science 1997;276:111-113. 2. Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenayi A. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol 1997; 7:1003-1006.
Additional info: Recognizes human DcR2.

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