DcR2, ID (Decoy Receptor 2, CD264, TNF-related Apoptosis-inducing Ligand Receptor 4, TRAIL Receptor 4, TRAILR4, TRAIL-R4, TRAIL Receptor with a Truncated Death Domain, TRUNDD, Tumor Necrosis Factor Receptor Superfamily Member 10D, TNFRSF10D, UNQ251/PRO288

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.\n\nApplications:\nSuitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000-1:2000\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nWhole cell lysate from HeLa cells\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D1500-05B

Size

50ug

Applications

ELISA, ICC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Pan, G. et al. Science 276, 111 (1997). 2. Pan, G. et al. Science 277, 815 (1997). 3. Sheridan, JP. et al. Science 277, 818 (1997). 4. Marsters, SA. et al. Curr Biol 7, 1003 (1997). 5. Degli-Esposti, MA. et al. Immunity 7, 813 (1997). 6. Pan, G. et al. FEBS Lett 424, 41 (1998).

Additional Info

Recognizes human DcR2. Species Crossreactivity: mouse and rat.