Home  >  Products  >  DDR1, CT (Discoidin Domain Receptor 1, CAK, CD167, EC 2.7.10.1, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE)
DDR1, CT (Discoidin Domain Receptor 1, CAK, CD167, EC 2.7.10.1, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE)

DDR1, CT (Discoidin Domain Receptor 1, CAK, CD167, EC 2.7.10.1, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE)

Cat no: D1649-03E

Supplier: United States Biological
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CD167 is a 125kD protein which is partially processed into a 62kD membrane-anchored beta -subunit and a 54kD soluble alpha-subunit. This process, also termed shedding, is significantly enhanced upon CD167 activation. CD167 has been demonstrated to be a direct transcriptional target of the p53 tumor suppressor gene, and is significantly over-expressed in breast, ovarian, oesophageal, and paediatric brain tumors. Applications: Suitable for use in Immunohistochemistry (paraffin). Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 20-30ug/ml Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D1649-03E
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Vogel, W.F. et al. (2006) Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signal. 18:1108-1116.
Additional info: Recognizes human CD167.

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