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DDR1, CT (Discoidin Domain Receptor 1, CAK, CD167, EC 2.7.10.1, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE)

Cat no: D1649-03E

DDR1, CT (Discoidin Domain Receptor 1, CAK, CD167, EC 2.7.10.1, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE)

CD167 is a 125kD protein which is partially processed into a 62kD membrane-anchored beta -subunit and a 54kD soluble alpha-subunit. This process, also termed shedding, is significantly enhanced upon CD167 activation. \n\nCD167 has been demonstrated to be a direct transcriptional target of the p53 tumor suppressor gene, and is significantly over-expressed in breast, ovarian, oesophageal, and paediatric brain tumors.\n\nApplications:\nSuitable for use in Immunohistochemistry (paraffin). Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 20-30ug/ml\nRequires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

D1649-03E

Size

50ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.7, 0.09% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Vogel, W.F. et al. (2006) Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signal. 18:1108-1116.

Additional Info

Recognizes human CD167.

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