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DEC1 (DEC-1, Differentially Expressed in Chondrocytes, Differentiated Embryo Chrondrocyte Expressed Gene 1, BHLHB2, Basic Helix-Loop-Helix Domain Containing Class B 2, SHARP2, SHARP-2, STRA13, STRA14)

Cat no: D1824-01A

DEC1 (DEC-1, Differentially Expressed in Chondrocytes, Differentiated Embryo Chrondrocyte Expressed Gene 1, BHLHB2, Basic Helix-Loop-Helix Domain Containing Class B 2, SHARP2, SHARP-2, STRA13, STRA14)

Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is an important protein involved in embryonic cell differentiation, proliferation, and apoptosis. It has also recently been shown to be regulated by hypoxia. The loss of DEC1 expression may be an early event in the development of lung cancer, while DEC1 may be up-regulated by hypoxia in other cancers and in more extreme hypoxia it may have a role in cell death.\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:5000-1:15,000\nImmunoprecipitation: 1-4ug/mg of lysate\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D1824-01A

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid, 0.09% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Liu Y, Sato F, Kawamoto T et al. Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells. Genes Cells. 2010 Apr 1;15(4):315-25.

Additional Info

Recognizes human DEC1.

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