Home  >  Products  >  Dectin-1 (C-type Lectin Domain Family 7 Member A, Dendritic Cell-associated C-type Lectin 1, DC-associated C-type Lectin 1, Beta-glucan Receptor, beta-GR, C-type Lectin Superfamily Member 12, CLEC7A, BGR, CLECSF12, DECTIN1, UNQ539/PRO1082) (FITC)
Dectin-1 (C-type Lectin Domain Family 7 Member A, Dendritic Cell-associated C-type Lectin 1, DC-associated C-type Lectin 1, Beta-glucan Receptor, beta-GR, C-type Lectin Superfamily Member 12, CLEC7A, BGR, CLECSF12, DECTIN1, UNQ539/PRO1082) (FITC)

Dectin-1 (C-type Lectin Domain Family 7 Member A, Dendritic Cell-associated C-type Lectin 1, DC-associated C-type Lectin 1, Beta-glucan Receptor, beta-GR, C-type Lectin Superfamily Member 12, CLEC7A, BGR, CLECSF12, DECTIN1, UNQ539/PRO1082) (FITC)

Cat no: D1876-48P5

Supplier: United States Biological
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Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells. As a major leukocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: Neat-1;10; 10ul labels 10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Hybridoma: Rat Y3 myeloma cells with spleen cells from Fisher Rat. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.
Catalogue number: D1876-48P5
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.09% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
References: 1. Brown, G. D. et al. (2002) J. Exp. Med. 196:407-412.2. Taylor, P. R. et al. (2002) J. Immunol. 169:3876-3882.3. Reid, D.M. et al. (2004) J. Leuk. Biol. 76:86-94.4. Underhill, D.M. et al. (2005) Blood 106:2543-2550.5. Lefevre,L. et al. (2010) Plos One. 5(9):e12828.6. Fei, M. et al. (2011) Proc Natl Acad Sci U S A. Mar 14. [Epub ahead of print]7. Gazi, U. et al. (2011) J Biol Chem. 286: 7822-9.8. McDonald, J.U. et al. (2011) FASEB J. Mar 2. [Epub ahead of print]9. Dewals, B.G. et al. (2010) PLoS Negl Trop Dis. 4: e689.10. Gal
Additional info: Recognizes mouse beta-glucan receptor, also known as Dectin-1. Inhibits the binding of zymosan to macrophages via the beta-glucan receptor.

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