Deslorelin

Deslorelin is a potent LHRH/GnRH agonist has a molecular formula of C64H83N17O12 Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt having a Mw of 1282.47. Deslorelin is being studied in the treatment of cancer as a way to block sex hormones made by the ovaries or testicles. It belongs to the family of drugs called gonadotropin-releasing hormone analogs. It is used for the induction of ovulation in mares. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production.\n\nDimers and Aggregates: \nLess than 1% as determined by silver-stained SDS-PAGE gel analysis.\n\nEndotoxin: \n(same/less than) 0.1ng/ug (IEU/ug) of Deslorelin.\n\nProtein Content: \nProtein quantitation was carried out by two independent methods:\n1. UV spectroscopy at 280 nm.\n2. Analysis by RP-HPLC, using a calibrated solution of Atosiban as a Reference Standard.\n\nSolubility: \nIt is recommended to reconstitute the lyophilized Deslorelin in sterile 18MOmega-cm H2O not less than 100microg/ml, which can then be further diluted to other aqueous solutions.\n\nStability: \nLyophilized Deslorelin although stable at room temperature for 3 weeks, should be stored desiccated below -180C. Upon reconstitution Deslorelin should be stored at 40C between 2-7 days and for future use below -180C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

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