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DNA Methyltransferase 2 (Dnmt2, DNA Cytosine 5 Methyltransferase 2 Like Protein 2, DNA Methyltransferase Homolog HsaIIP, PuMet)

DNA Methyltransferase 2 (Dnmt2, DNA Cytosine 5 Methyltransferase 2 Like Protein 2, DNA Methyltransferase Homolog HsaIIP, PuMet)

Cat no: D3931-62A

Supplier: United States Biological
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Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases. Cellular Localization: Nuclear Positive Control: transfected cell lysate Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D3931-62A
Reactivities: Mouse
Hosts: Mouse
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Mab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: Yoder JA & Bestor TH A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast. Hum Mol Genet 7:279-84 (1998). Okano M et al. Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res 26:2536-40 (1998).
Additional info: In mouse Dnmt2 transfected cell lysate, a 42kD band is oberseved. Species Crossreactivity: Crossreacts with Mouse.

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