Extractable Nuclear Antigen, Human, IgG, BioAssay(TM) ELISA Kit (ENA)

The United States Biological Extractable Nuclear Antigen, Human, IgG, BioAssay(TM) ELISA Kit is designed to detect IgG class antibodies to Jo-1, Sm, Sm/RNP, SSA(Ro), SSB(La), and Scl-70 in human serum. Wells of plastic microwell strips are sensitized by passive absorption with immobilized antigens. In recent years it has become clear that autoantibodies to a number of nuclear constituents have proven to be useful in the diagnosis of various connective tissue diseases. The Jo-1 autoantibody is one of a family of characteristic autoantibodies seen in myositis patients. They are all specifically found in patients with myositis, and are all associated with a high incidence of accompanying interstitial lung disease. Antibodies directed against the Sm marker are highly specific for patients with SLE and are considered a diagnostic criterion for SLE. The presence of high level RNP antibodies alone are considered diagnostic of mixed connective tissue disease (MCTD) and are usually associated with a more benign disease course, while patients with low levels of RNP antibodies, together with other autoantibodies, may be observed in the serum of patients with progressive systemic sclerosis, Sj

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SPECIFICATIONS

Catalog Number

E9011

Size

1Kit

Applications

ELISA

Reactivities

Hum

References

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