Fatty Acid Binding Protein 5, Epidermal, Recombinant, Human (EFABP, FABP5, mal1, MGC133132)

Human Fatty Epidermal Acid Binding Protein FABP also called FABP-5 is a 15kD member of the intracellular fatty acid binding protein (FABP) family, which is known for the ability to bind fatty acids and related compounds ( bile acids or retinoids). in an internal cavity. The fatty acid binding proteins aP2 (fatty acid binding protein [FABP]-4) and mal1 (EFABP) are closely related and both are expressed in adipocytes. Absence of EFABP/mal1 resulted in increased systemic insulin sensitivity in two models of obesity and insulin resistance. Adipocytes isolated from mal1-deficient mice also exhibited enhanced insulin-stimulated glucose transport capacity. In contrast, mice expressing high levels of mal1 in adipose tissue display reduced systematic insulin activity.\n\nRecombinant Human Epidermal Fatty Acid Binding Protein(FABP-5) is a monodimeric, non-glycosylated, polypeptide chain containing 135 amino acids and having a total molecular mass of 15200 Daltons.\n\nSpecificity: \nThe amino acid sequence of the recombinant human FABP5 is 100% homologous to the amino acid sequence of the human FABP-5.\n\nApplications: \nWestern blotting, ELISA\n\nReconstitution: \nAdd 0.2 ml of dH20 and let the lyophilized pellet dissolve completely.\n\nStorage: \nStore lyophilized protein at -20 degrees C. Aliquot the product after reconstitution to avoid freeze-thaw cycles. Reconstituted protein can be stored at 4 degrees C for a limited period of time; it does not show any change after two weeks at 4 degrees C.

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SPECIFICATIONS

Catalog Number

F0019-86

Size

2ug

Form

Supplied as a lyophilized powder in PBS.

Purity

(same/more than) 90% (SDS-PAGE); Two-step procedure using size exclusion chromatography before and after refolding.

References

1. Metastasis of squamous cell carcinoma of the oral tongue is associated with down-regulation of epidermal fatty acid binding protein (E-FABP).\n\nOral Oncol 2006 Jun 5;\n\n2. Decreased keratinocyte motility in skin wound on mice lacking the epidermal fatty acid binding protein gene.\n\nMol Cell Biochem 2006 Mar;284(1-2):183-8\n\n3. Epidermal fatty acid-binding protein is increased in rat lungs following in vivo treatment with keratinocyte growth factor.\n\nInt J Biochem Cell Biol 2006 Feb;38(2):279-87\n\n4. S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes.\n\nJ Invest Dermatol 2003 Jul;121(1):132-41\n\n5. Lack of upregulation of epidermal fatty acid binding protein in dithranol induced irritation.\n\nEur J Dermatol 2003 May-Jun;13(3):254-7\n\n6. Induction of epidermal fatty acid binding protein in intravascular monocytes of renal allografts.\n\nTransplantation 2003 Mar 15;75(5):685-8